Because tricyclic antidepressants are anticholinergic, they also tend to hinder memory formation.Remeron is a good choices for the management of insomnia.(Since histamine plays a role in maintaining wakefulness, antihistamines like Remeron or Benedryl promote sleep).The serotonin receptor 5HT2A is also thought to play a role in sleep/wake regulation, and 5HT2A blockade likely accounts for Remeron’s tendency to enhance slow wave sleep (SWS).As can be seen from the above table, Remeron antagonizes (blocks) with high affinity histamine receptors (specifically, the H1 subtype), as well as the serotonin receptor 5HT2A.
Remeron perhaps outperform other antidepressants because it treats both insomnia and depression. Other effective antidepressants, like SSRIs, tend to exacerbate insomnia.Benzodiazepines and z-drugs both affect the GABA receptor in the brain.Long-term use of these sleep aids can result in protracted cognitive impairment.Interviewer: Sedation is commonly used in the intensive care unit to make patients that require mechanical ventilation more comfortable and less anxious.
What many don't realize is that sedation can have side effects that can endanger the patient's life. Richard Barton, Director of Surgical Critical Care at the University Hospital, and Nick Lonardo, Pharmacy Clinical Coordinator are investigating best practices for sedation use in the ICU. Barton, what is the problem that you're concerned with? Richard Barton: First, let me describe the patients that we have in the surgical and intensive care units. That means we have a machine that helps the patient breathe, but in order to do this these people have an endotracheal tube, which is stiffer and bigger than a soda straw, smaller than a garden hose. Richard Barton: Yes, well, imagine what it feels like when you stick your finger down your throat; it makes you throw up.We can have patients with trauma, with sepsis, with major surgical complications. But the point is it is through the patient's open mouth, through their vocal chords, and into their trachea. Imagine having that sensation for hours, days, weeks.